I am going through my initial round of infusions, and have my 6th one tomorrow. I’m ready to stop having IVs in my arms at least - I have tiny veins and lots of bruising. I didn’t notice anything after the first two - the third one was good, and improved my depression a moderate amount. The fourth one did as well, which I thought meant it would just keep on working better. At that point, my depression went from a 10/10 to a 5/10. Great improvement, but still not where I would realistically want to end up as “cured.” After my 5th infusion, I noticed an increase in my depression once again, which is making me a bit afraid that I might not respond well after the 6th and final infusion. I’m better so far, but definitely don’t feel amazing or anything. Has anyone else experienced this increase in depression before treatments are even over? Since ketamine is like a last-resort sort of thing, it would be discouraging if it ends up fading so quickly.
I have tried 6 meds so far, and many years of therapy. I also have Schizoid PD, which may be an interference? I wouldn’t think it would reduce the effectiveness of ketamine on depression, though. I just really don’t want to be disappointed after I finally thought there was some effectiveness going on…
I haven’t had any particular traumatic events to unpack - my depression is the type that almost seems purely biological in its weight. No negative thought patterns or bringing myself down, etc. Just pure depression that ends up feeling physical and unbreakable. There was a moderate reduction after my 3rd and 4th infusions, but not anything extreme.
I’m not sure if I’m looking for reassurance or realism, but I’d take both. Has anyone else experienced a return of depression like this during treatment? Did it go away after the last infusion? Did treatment end up not working? etc. This is my first post here so hopefully this is the right place to ask.