Does anyone know if having the MTHFR gene negatively affects ketamine response?

New here, haven’t started infusions yet. I’d really like to but I had genetic testing and I have the MTHFR gene (homozygous for 1298 variant) so not sure if that could dampen or negate ketamine efficacy. Wondering if anyone here who’s had a positive ket infusion experience also has the MTHFR gene or has more info on this…? Hope the day is treating everyone well.