How do the effects differ?
I’ve done infusions and used compounded ketamine nasal spray (different than esketamine (spelling?) nasal spray you do in a dr office). The nasal spray has a much lower bioavailability than iv so the experience is a lot less intense. I tried nasal spray instead of lozenges/troches but the lozenges were easier for me and seem to have a better effect.
Got it, that makes sense. Thanks for the reply! Did you prefer the lozenges to the infusions?
I had ketamine as an anesthetic after surgery and experienced complete remission of depression, anxiety, and suicidal ideation. That effect remained for a few weeks.
I am now trying nasal ketamine (generic, not esketamine) and it helps with depression but the effect isn’t nearly as strong as the IV was for surgery (and it’s certainly a much smaller dose, too).
Yes. Ive done IV infusion, Spravato (nasal spray) and a compounded nasal spray. The Spravato is initially intense because for me the nasal spray gets into my bloodstream pretty quickly. Within 10 minutes i feel the effect. The compounded nasal spray did absolutely nothing for me. No effect at all…The IV infusion gives me more of a psychedelic experience (i typically feel like I am floating in outer space like an astronaut and have kind of an out of body experience). It came on slower for me. Maybe 20-25 min i started to feel the impact. Its definitely more intense as far as how long it lasts…- around half an hour overall. The Spravato hit me much faster but i didn’t get the same psychedelic experience as with infusion treatment and it didn’t last as long.
Infusion is the best. Lozenges help to maintain the effects of the infusion. I have not tried the nasal spray!