My boyfriend (late thirties) has had MDD for some 20 years, worsened over the last 5 years. He has tried all the drugs, TMS, ECT, all failed. Therapy has been only marginally useful.
It seemed like Ketamine infusions were working. After the first 7 infusions he had about 5 days being depression-free. However, he soon relapsed, with an apparently worse crash episode than is typical. 3 additional infusions over the course of a week had no effect in lifting his mood. He stayed in bed and was not functional for 10 days.
He has now had 14 infusions in total over 8 weeks. We are wondering whether and when to call it quits. His parents are paying for the treatments, and it is so damn expensive, especially to continue without seeing any results in the hopes that the ketamine could be having some long term benefits which are not at all apparent right now…
Since there is so little evidence, we are looking for anecdotal experiences, if you have anything to share about Ketamine ultimately appearing to fail.
Thank you for your help.